Lactation without Pregnancy

What Causes Lactation Without Pregnancy: Its Diagnosis and Remedy

Lactation in the absence of pregnancy is a rare medical condition that usually affects women but occurs in men and infants too. While this condition, caused due to several factors, is not something to worry about, it could indicate pituitary tumors and hormonal imbalances among others. This article has more information in this regard.
Lactation
Lactation, defined as the secretion of milk from the mammary glands, is completely normal for a woman who is pregnant or just had a baby. This is because the oxytocin hormone that is produced after the birth of the baby, stimulates uterine contractions and provides an impetus for the lactation process to start.
What is Galactorrhea?
In certain cases, you can have lactation or discharge from the breasts without being pregnant or breastfeed. This condition is known as galactorrhea. Associated with a milky white discharge from the breasts without nursing or pregnancy, galactorrhea is a sign of some underlying problem like a disorder of the pituitary gland or side effects of medications. It affects not only women but also men and infants in rare instances. Here are some of the common causes of lactation without pregnancy.
Occurrence of Galactorrhea
According to the American Academy of Family Physicians, galactorrhea occurs in roughly 20 to 25 percent of women.
Causes of Lactation Without Pregnancy
Medications Causing Lactation Without Pregnancy
Certain medications like tranquilizers, drugs for high pressure, and antidepressants can result in lactation without pregnancy. Common medications associated with galactorrhea include agents to block dopamine and histamine receptors and dopamine-depleting agents. Birth control pills can also induce lactation. This is because the estrogen in these pills suppresses the hypothalamic secretion of the prolactin inhibitory factor and stimulates lactotrophs. In such cases, consult a doctor immediately.
Pituitary Tumors
The most common cause of galactorrhea is a tumor in the pituitary gland. Benign tumors like prolactinoma result in the production of prolactin. Too much prolactin in the blood causes the stimulation of milk by the mammary glands along with other symptoms like tenderness in the breasts, headache, decreased sexual activity, infertility and irregular menstruation. These non-cancerous tumors can affect men as well and result in decreased sexual drive, impotence and enlargement of the breast tissues.
Hypothyroidism
It is a rare cause of galactorrhea but, primary hypothyroidism can lead to an increase in the production of the thyrotropin-releasing hormone. This leads to the release of excess prolactin and lactation. Hyperprolactinemia (excess of prolactin) can also cause a drop in the metabolic clearance of prolactin and a decrease in the secretion of dopamine.
Chronic Renal Failure
In certain rare cases, people with chronic kidney disease have high levels of prolactin due to the inability of the kidneys to clear the prolactin. This can also lead to discharge from the nipples.
Other Causes
Certain neurogenic causes can also result in lactation without breastfeeding or pregnancy. Extensive and prolonged breast stimulation during sex or during breast examination can lead to galactorrhea. Other causes include injuries and damage to the chest, spinal cord injuries, and tumors. Certain herbs like fennel, fenugreek, and blessed thistle can also induce lactation.
Sometimes, when the cause of galactorrhea cannot be discerned, it is termed as idiopathic galactorrhea. While it is more common in women, even men can be affected with galactorrhea. Testosterone deficiency, also known as male hypogonadism, is one of the main reasons for this. Other than lactation, testosterone deficiency can also lead to erectile dysfunction and loss of sexual desire. In newborns, galactorrhea is caused by the circulation of high estrogen from the mother to the baby in the placenta. This causes an enlargement of breasts along with a milky discharge, which is often termed as witch's milk.
Diagnosis of Galactorrhea
Ascertaining the cause of galactorrhea:
  • A physical examination to check the nipple discharge and signs of thickened breast tissues or lumps are done.
  • MRI, mammography, and blood tests can help in diagnosing the problem.
  • A pregnancy test needs to be done for all post-pubertal women.
  • It is important to note that galactorrhea is associated with milky white discharge. If the discharge from the breasts is bloody, then it is not associated with galactorrhea.
Treatment of Galactorrhea
For an underactive thyroid or tumors of the pituitary glands, appropriate medication and treatment need to be provided, based on the underlying cause.
  • Pituitary tumors need to be treated with medicines like bromocriptine.
  • In case medications fail to work, surgery and radiation therapy are used for treating the tumor.
  • In case of idiopathic galactorrhea where the cause is unknown, prolactin-reducing medications like cabergoline can be prescribed to reduce the discharge.
Once the cause of lactation is found and appropriate treatment is provided, it should stop completely. In case of mild idiopathic galactorrhea, well-fitted padded bras can keep the discharge from staining the clothes. Prevent unwanted lactation by frequent breast examinations and avoiding tight clothing that causes friction with the nipples.
Disclaimer: This article is for informative purposes only and should not be used as a replacement for professional medical advice.